Groundbreaking Research on Brain Estrogen Receptors
Anna Harrelson • June 22, 2024

New Insights into Estrogen’s Role in Brain Health During Menopause: A Groundbreaking Study by Dr. Lisa Mosconi

Hello everyone,

Exciting news from the world of menopause research! Dr. Lisa Mosconi's latest study, published in Nature, offers groundbreaking insights into how estrogen affects our brains during menopause. This research sheds light on the vital role of estrogen receptors (ERs) in maintaining brain health and cognitive function through the menopause transition.



The Study Highlights

Dr. Mosconi's team conducted a pioneering in vivo study using PET scans to measure ER density in the brains of midlife women. The findings reveal that ER density increases over the menopause transition, independent of age and hormone levels. This increase in ER density is associated with poorer memory performance and a higher incidence of mood and cognitive symptoms in postmenopausal women.

Key Findings

  • ER Density and Menopause: The study found progressively higher ER density in the brains of postmenopausal women compared to premenopausal and perimenopausal women. This was consistent across various brain regions involved in cognitive and emotional functions.
  • Cognitive Impacts: Higher ER density in regions like the hippocampus and frontal cortex was linked to lower memory scores and increased mood symptoms, highlighting the critical role of estrogen in brain health.
  • Symptom Prediction: The study also demonstrated that ER density could predict the presence of mood and cognitive symptoms, such as depression and memory issues, in postmenopausal women.


The Importance of Estrogen

Estrogen, particularly 17β-estradiol, is crucial for various brain functions, including memory, mood regulation, and protection against neurodegeneration. As estrogen levels decline during menopause, the brain undergoes significant changes, which can lead to symptoms like brain fog, mood swings, and memory lapses.


Implications for Menopause Care

This research underscores the importance of hormone replacement therapy (HRT) and other menopause care strategies. By understanding how estrogen receptors affect the brain, healthcare providers can better tailor treatments to support cognitive and emotional health in menopausal women.


Practical Tips for Maintaining Brain Health

  1. Consider HRT: Consult with your menopause doctor about the benefits of HRT for maintaining cognitive health.
  2. Stay Physically Active: Regular exercise can improve blood flow to the brain and support cognitive function.
  3. Eat a Brain-Healthy Diet: Focus on anti-inflammatory foods rich in omega-3 fatty acids, antioxidants, and vitamins.
  4. Manage Stress: Practice mindfulness, meditation, or yoga to reduce stress and its impact on brain health.
  5. Stay Mentally Active: Engage in activities that challenge your brain, such as puzzles, reading, and learning new skills.

Dr. Mosconi's research is a game-changer in our understanding of menopause and brain health. By prioritizing estrogen's role in the brain, we can develop better strategies for managing menopause symptoms and improving quality of life for midlife women.

For more details on this groundbreaking study, check out the full article here.


In Health,

Dr. Anna

WonderCreek Health Blog

By Anna Harrelson June 13, 2025
You’ve probably seen it popping up in wellness podcasts, health stores, or even your friend's supplement cabinet: bovine colostrum. Marketed for gut health, immune support, and recovery, this early-life nutrient source for calves is now showing up in adult wellness routines. But is it worth your time and money? As a lifestyle medicine physician focused on women’s midlife health and longevity, here’s what I want you to know before you jump on the colostrum bandwagon. Let’s Start With the Basics: What Is Colostrum? Colostrum is the first form of milk produced by mammals (including humans) in the first few days after giving birth. It’s loaded with antibodies, growth factors, and immune-modulating compounds designed to jumpstart a newborn’s immune system and line the gut. Bovine colostrum—from cows—is the form used in most supplements. It's freeze-dried and packaged into powders or capsules, and often promoted for: Gut barrier support ("leaky gut") Immune system priming Exercise recovery Anti-aging benefits But let’s be honest: just because something has growth factors doesn’t mean it belongs in your Amazon cart. Does the Science Support It? Evidence in humans is limited— but not nonexistent. Some small clinical studies have shown potential benefits: Gut health: In people with NSAID-induced intestinal permeability ("leaky gut"), bovine colostrum has been shown to reduce damage and symptoms. Immune function: Some data in athletes suggests reduced upper respiratory infections. Exercise recovery: A few studies report improvements in performance, gut comfort, or muscle soreness—especially in endurance athletes. But these benefits aren’t guaranteed. And the quality and dosage of colostrum varies widely, with no standardized formulation across brands. So Should You Take It? Here’s where my clinical voice kicks in: Before you reach for colostrum, ask yourself: Have you addressed the basics? Are you sleeping? Managing stress? Eating fiber and whole foods? Getting enough protein? Building muscle? Moving your body? Supporting your gut with real food (not just powders)? If the answer is no—then colostrum is not your next step. You’re throwing powdered fuel on an engine that’s missing spark plugs. Do you have dairy sensitivity? Colostrum is a dairy product. Even if it's low in lactose, it may not be tolerated by everyone. Are you already taking quality foundational supplements? Vitamin D, omega-3s, magnesium, creatine, iron (when needed), and probiotics have stronger bodies of evidence for many women in midlife. When Might It Be Worth Trying? Colostrum might be a reasonable add-on if you: Have mild gut symptoms (especially post-infectious or stress-related) Are recovering from illness or antibiotics Train hard and experience frequent upper respiratory issues Want to support your immune system during travel or stress Even then, I recommend: A 2–3 month trial only after dialing in basics Choosing a third-party tested brand Tracking symptoms and benefits Cost, Hype, and the Bigger Picture Many women I work with are overwhelmed by supplement costs. Colostrum can run $50–100/month —and that adds up. So here’s what I tell my patients: Just because something is trending doesn’t mean it’s essential. And just because it works for someone on TikTok doesn’t mean it’s the right tool for your body right now. Your body is an incredible machine. When you give it rest, movement, nourishment, and support—it can do amazing things. Colostrum is not magic. It’s just one tool in a very big toolbox. Bottom Line Colostrum may hality sources. You’re not broken. You might just need a reset—not another powder.
By Anna Harrelson June 12, 2025
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