Wait, Should I Be Taking Creatine?
Anna Harrelson • March 12, 2025

Why this gym supplement is gaining traction for women’s hormones, energy, mood, and healthy aging.

Creatine is one of the most well-studied, safe, and effective supplements not only for muscle performance—which is what it's most famous for—but also for brain health, metabolism, and perimenopause support. Here's a deep dive into the science behind creatine’s value, particularly relevant for women in midlife:

๐Ÿ”ฌ What is Creatine?
Creatine is a naturally occurring compound made in the liver, kidneys, and pancreas from three amino acids: arginine, glycine, and methionine. It’s stored in muscles (95%) and the brain (5%) as phosphocreatine, which serves as a rapid energy reserve for cells, especially during times of high demand.

We get creatine from animal products (red meat, fish), but vegetarians and women in general often have lower baseline levels. That's why I supplement daily! 

๐Ÿง  1. Creatine & Brain Health
The brain uses a tremendous amount of energy, especially during stress, hormonal fluctuation, and cognitive tasks. Creatine helps recycle ATP (adenosine triphosphate)—our primary energy currency—so brain cells can keep firing efficiently.

Key Benefits:
  • Improved mental fatigue resistance (especially during sleep deprivation or high-stress)
  • Better working memory, attention, and cognitive flexibility
  • Neuroprotection: May protect against oxidative stress and support mitochondrial health
  • Mood support: Preliminary studies show benefits in depression, especially in women with treatment-resistant depression or PMDD
ADHD & executive function: Enhances dopamine signaling and helps with focus and emotional regulation
๐Ÿงช One 2022 meta-analysis found that creatine improved aspects of short-term memory and reasoning in healthy adults, with women and older adults seeing the most benefit.

๐Ÿ’ช 2. Muscle Mass, Strength & Longevity
Creatine enhances muscle performance, power, and recovery, especially in aging adults and women in midlife, where we naturally lose muscle mass and strength (sarcopenia risk increases after 40).

Key Benefits:
Increased muscle protein synthesis
Improved response to resistance training
Supports healthy aging and fall prevention
Reduces exercise-induced fatigue and muscle soreness
โœ… Important for healthspan: Women with better muscle strength and power have lower risk of metabolic disease, disability, and frailty in later life.

๐Ÿงฌ 3. Hormonal & Metabolic Support in Perimenopause
Estrogen plays a role in energy metabolism and mitochondrial function—both of which decline during perimenopause. Creatine helps buffer this by:
  • Supporting mitochondrial ATP production
  • Improving insulin sensitivity
  • Assisting in glucose uptake and lean mass preservation
  • Reducing inflammatory markers in some studies
๐Ÿ”ฅ This makes it particularly helpful for women going through perimenopause, menopause, and those with insulin resistance or metabolic syndrome.

๐Ÿฆด 4. Bone Density
Some studies show creatine, especially when combined with resistance training, may support bone mineral density—critical for women at increased osteoporosis risk.

๐Ÿฉบ 5. Safety & Dosing
Creatine is extremely well-studied and safe in recommended doses:
Note: Can cause minor water retention in muscles initially, but not dangerous.

๐ŸŒŸ Summary: Who Should Consider Creatine?
โœ… Perimenopausal & menopausal women (100% ME!!!)
โœ… Women with fatigue, low mood, or brain fog (occasionally, me)
โœ… Vegetarians / low red meat eaters (me)
โœ… People with ADHD or depression (that's me)
โœ… Anyone strength training or focused on aging well (and also, that's me!!!)

WonderCreek Health Blog

By Anna Harrelson June 13, 2025
You’ve probably seen it popping up in wellness podcasts, health stores, or even your friend's supplement cabinet: bovine colostrum. Marketed for gut health, immune support, and recovery, this early-life nutrient source for calves is now showing up in adult wellness routines. But is it worth your time and money? As a lifestyle medicine physician focused on women’s midlife health and longevity, here’s what I want you to know before you jump on the colostrum bandwagon. Let’s Start With the Basics: What Is Colostrum? Colostrum is the first form of milk produced by mammals (including humans) in the first few days after giving birth. It’s loaded with antibodies, growth factors, and immune-modulating compounds designed to jumpstart a newborn’s immune system and line the gut. Bovine colostrum—from cows—is the form used in most supplements. It's freeze-dried and packaged into powders or capsules, and often promoted for: Gut barrier support ("leaky gut") Immune system priming Exercise recovery Anti-aging benefits But let’s be honest: just because something has growth factors doesn’t mean it belongs in your Amazon cart. Does the Science Support It? Evidence in humans is limited— but not nonexistent. Some small clinical studies have shown potential benefits: Gut health: In people with NSAID-induced intestinal permeability ("leaky gut"), bovine colostrum has been shown to reduce damage and symptoms. Immune function: Some data in athletes suggests reduced upper respiratory infections. Exercise recovery: A few studies report improvements in performance, gut comfort, or muscle soreness—especially in endurance athletes. But these benefits aren’t guaranteed. And the quality and dosage of colostrum varies widely, with no standardized formulation across brands. So Should You Take It? Here’s where my clinical voice kicks in: Before you reach for colostrum, ask yourself: Have you addressed the basics? Are you sleeping? Managing stress? Eating fiber and whole foods? Getting enough protein? Building muscle? Moving your body? Supporting your gut with real food (not just powders)? If the answer is no—then colostrum is not your next step. You’re throwing powdered fuel on an engine that’s missing spark plugs. Do you have dairy sensitivity? Colostrum is a dairy product. Even if it's low in lactose, it may not be tolerated by everyone. Are you already taking quality foundational supplements? Vitamin D, omega-3s, magnesium, creatine, iron (when needed), and probiotics have stronger bodies of evidence for many women in midlife. When Might It Be Worth Trying? Colostrum might be a reasonable add-on if you: Have mild gut symptoms (especially post-infectious or stress-related) Are recovering from illness or antibiotics Train hard and experience frequent upper respiratory issues Want to support your immune system during travel or stress Even then, I recommend: A 2–3 month trial only after dialing in basics Choosing a third-party tested brand Tracking symptoms and benefits Cost, Hype, and the Bigger Picture Many women I work with are overwhelmed by supplement costs. Colostrum can run $50–100/month —and that adds up. So here’s what I tell my patients: Just because something is trending doesn’t mean it’s essential. And just because it works for someone on TikTok doesn’t mean it’s the right tool for your body right now. Your body is an incredible machine. When you give it rest, movement, nourishment, and support—it can do amazing things. Colostrum is not magic. It’s just one tool in a very big toolbox. Bottom Line Colostrum may hality sources. You’re not broken. You might just need a reset—not another powder.
By Anna Harrelson June 12, 2025
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